The Furry Critter Network

Malignant Histiocytosis - Issue Description

Issue Name

Malignant Histiocytosis

Other Names
N/A

Issue Description

Malignant histiocytosis is a rare hereditary disease found in the Bernese Mountain Dog characterized by histiocytic infiltration of the lungs and lymph nodes. The liver, spleen, and central nervous system can also be affected. Histiocytes are a component of the immune system that proliferate abnormally in this disease.

Symptoms

The disease in the lungs is characterized by enlargement of the tracheobronchial lymph nodes and infiltration of the lungs, sometimes leading to lung lobe consolidation and pleural effusion. Signs and symptoms include cough, loss of appetite, weight loss, anemia, and difficulty breathing. Seizures and rear limb weakness can be seen. Invasion of the bone marrow can cause pancytopenia.

Diagnosis

Diagnosis requires a biopsy.

Histiocytic Disorders

A histiocyte is a differentiated tissue cell that has its origin in the bone marrow. The source for histiocytes is the monocyte/macrophage line. Monocytes (found in the blood) and macrophages (found in tissue) are responsible for phagocytosis (ingestion) of foreign material in the body. Langerhans cells are dendritic cells found in the skin and function by internalizing antigens (foreign particles) and presenting them to T cells. They arise from monocytes. Histiocytic disorders refer to diseases that are caused by abnormal behavior of these cells.

They include the following:

Reactive Diseases of Langerhans Cells

Histiocytomas

Cutaneous histiocytosis

Systemic histiocytosis

Reactive Diseases of Macrophages

Hemophagocytic syndrome

A condition where macrophages phagocytose myeloid and erythroid precursors (similar to hemophagocytic lymphohistiocytosis in humans)

Malignant diseases of Langerhans dells

Malignant histiocytosis

A condition found in Bernese Mountain Dogs

Diffuse histiocytic sarcoma

Localized histiocytic sarcoma

Malignant Diseases of Macrophages

Histiocytic lymphoma

Breed Disposition

Up to 25 percent of Bernese Mountain Dogs may develop malignant histiocytosis in their lifetime. Other breeds with a possible genetic tendency toward malignant histiocytosis include Rottweilers, Flat-Coated Retrievers, and Golden Retrievers.

Treatment

Treatment with chemotherapy has been used with some success, particularly using lomustine, prednisone, doxorubicin, and cyclophosphamide. Because of the rapid progression of this aggressive disease, the prognosis is very poor.

Other Histiocytic Diseases In Bernese Mountain Dogs

A similar disease is diffuse histiocytic sarcoma, a term used to designate a localized histiocytic sarcoma that has spread throughout the body.

Another disease of histiocytic origin that affects Bernese Mountain Dogs is systemic histiocytosis. This condition generally begins as lesions on the eyelids, nasal mucosa, and skin, especially the scrotum. It progresses to a more generalized disease affecting the lymph nodes, bone marrow and spleen. Other signs and symptoms include weight loss and loss of appetite. It also has a very poor prognosis.

Back to Canine Health Issues Menu

Featured Rescues

"Don't Shop ... Please Adopt"

ASPCA

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) was the first humane society to be established in North America and is, today, one of the largest in the world.

Our organization was founded on the belief that animals are entitled to kind and respectful treatment at the hands of humans and must be protected under the law. Headquartered in New York City, the ASPCA maintains a strong local presence, and with programs that extend our anti-cruelty mission across the country, we are recognized as a national animal welfare organization. We are a privately funded 501(c)(3) not-for-profit corporation, and are proud to boast more than 2 million supporters across the country.

The ASPCA’s mission, as stated by founder Henry Bergh in 1866, is “to provide effective means for the prevention of cruelty to animals throughout the United States.”

Petfinder

If you can’t find the pet you’re looking for on Petfinder, don’t give up. Some shelters maintain waiting lists for specific breeds, so don’t be afraid to ask! There are also breed-specific rescues for just about every breed, and most of them post their pets on Petfinder. (Petfinder can even e-mail you when a pet that fits your criteria is posted — just click “Save this Search” at the top of your search results page.)

Rescue Me

Jeff Gold, Founder, Rescue Me! Animal Rescue Network

Jeff Gold lives in Watkinsville, Georgia on the same property as Rescue Me's Animal Rehabilitation Center, with 18 rescue animals. Shown with him in the photo to the left are Maggie, Izzie and Cortez. In 2003, after learning there was nobody doing boxer rescue work in Georgia, Gold founded Boxertown, an organization which helped find homes for over 500 boxers during its first two years. Based upon this success, Gold came up with the vision for Rescue Me! ― a network which helps all breeds of dogs, cats and other animals find good homes, anywhere in the world. RescueShelter.com is also a free service of Rescue Me! and provides the world's largest and most up-to-date directory of animal rescue organizations for all breeds of dogs, cats and other animals, including a comprehensive directory of wildlife rehabilitators in over 150 countries.

Top

Home » Contact » Service Terms » Privacy

Site Map

thanks for browsing!

Birds/Avian

Cats/Feline

Guinea Pigs/Cavy

Dogs/Canine

Dogs/Canine/Hybrid

Horses/Equine