The American Society for the Prevention of Cruelty to Animals® (ASPCA®) was the first humane society to be established in North America and is, today, one of the largest in the world.
Our organization was founded on the belief that animals are entitled to kind and respectful treatment at the hands of humans and must be protected under the law. Headquartered in New York City, the ASPCA maintains a strong local presence, and with programs that extend our anti-cruelty mission across the country, we are recognized as a national animal welfare organization. We are a privately funded 501(c)(3) not-for-profit corporation, and are proud to boast more than 2 million supporters across the country.
The ASPCA’s mission, as stated by founder Henry Bergh in 1866, is “to provide effective means for the prevention of cruelty to animals throughout the United States.”
The Furry Critter Network
Chronic Myelogenous Leukemia - Issue Description
Chronic Myelogenous Leukemia
Leukemia, Acute Lymphoid Leukemia, Canine Leukemia, ALL, Chronic Lymphocytic Leukemia, CLL, CML, Chronic Eosinophilic Leukemia, Hypereosinophilic Syndrome
Leukemia is a cancer of the blood and causes a large increase of white blood cells (leukocytes) either in the circulation or in the bone marrow. Leukemia can come from bone marrow or from lymph node cells.
Damage to the bone marrow, by way of displacing the normal bone marrow cells with higher numbers of immature white blood cells, results in a lack of blood platelets, which are important in the blood clotting process. This means patients with leukemia may become bruised, bleed excessively, or develop pinprick bleeds (petechiae).
White blood cells, which are involved in fighting pathogens, may be suppressed or dysfunctional. This could cause the patient's immune system to be unable to fight off a simple infection or to start attacking other body cells. Because leukemia prevents the immune system from working normally, some patients experience frequent infection, ranging from infected tonsils, sores in the mouth, or diarrhea to life-threatening pneumonia or opportunistic infections.
Finally, the red blood cell deficiency leads to anemia, which may cause dyspnea and pallor.
Some patients experience other symptoms. These symptoms might include feeling sick, such as having fevers, chills, night sweats and other flu-like symptoms, or feeling fatigued. Some patients experience nausea or a feeling of fullness due to an enlarged liver and spleen; this can result in unintentional weight loss. If the leukemic cells invade the central nervous system, then neurological symptoms (notably headaches) can occur.
All symptoms associated with leukemia can be attributed to other diseases. Consequently, leukemia is always diagnosed through medical tests.
The word leukemia, which means 'white blood', is derived from the disease's namesake high white blood cell counts that most leukemia patients have before treatment. The high number of white blood cells are apparent when a blood sample is viewed under a microscope. Frequently, these extra white blood cells are immature or dysfunctional. The excessive number of cells can also interfere with the level of other cells, causing a harmful imbalance in the blood count.
Some leukemia patients do not have high white blood cell counts visible during a regular blood count. This less-common condition is called aleukemia. The bone marrow still contains cancerous white blood cells which disrupt the normal production of blood cells. However, the leukemic cells are staying in the marrow instead of entering the bloodstream, where they would be visible in a blood test. For an aleukemic patient, the white blood cell counts in the bloodstream can be normal or low. Aleukemia can occur in any of the four major types of leukemia, and is particularly common in hairy cell leukemia.
Types Of Canine Leukemia
Leukemia (ALL) develops rapidly. Symptoms include loss of appetite, swelling of the lymph nodes, panting, pica (obsessive eating of non-food items such as clay, dirt, etc.), fever, bleeding, vomiting, pale gums, anxiousness. Infections will occur and are triggered by not having enough healthy, fully functional white blood cells. That as a result can cause rapid death if not treated immediately.
Contrary to humans, where acute leukemia is one of the most common childhood cancers, this cancer is mostly reported in mature dogs, not puppies or young animals.
Treatment for acute leukemia is similar to chronic leukemia but success rates are very poor. Most dogs live only a very short time after the disease has been diagnosed.
Chronic leukemia (CLL or CML) develops over time. The number of white blood cells increases less rapidly and the disease gets worse slowly over time. Again, due to the increased number of white blood cells the body cannot be protected properly from viruses or infections and the immune system will be suppressed. In addition a failure of the bone marrow and infiltration of cancer cells into organs will occur.
Chronic eosinophilic leukemia is a disease in which too many eosinophils (a type of white blood cell) are found in the bone marrow, blood, and other tissues. Chronic eosinophilic leukemia may stay the same for many years, or it may progress quickly to acute leukemia.
The hypereosinophilic syndrome is a disease process characterized by a persistently elevated eosinophil count in the blood for at least six months without any recognizable cause after a careful workup, with evidence of involvement of either the heart, nervous system, or bone marrow. Although HS has no certain aetiology, evidence suggests a link with chronic eosinophilic leukemia as it shows similar characteristics and genetic defects.
Treatments are done to reduce the number of white blood cells and lead normally to a temporary remission. In most cases the number of white cells will increase again, and as soon as the critical number is reached, treatments can be repeated. This remission - re-treatment can be done many times. Unfortunately, sooner or later, depending on individual cases, the chronic leukemia will turn into acute leukemia.
Some dogs have been known to live several months or even years until the acute leukemia takes over.
Significant research into the causes, diagnosis, treatment, and prognosis of leukemia is being done. Hundreds of clinical trials are being planned or conducted at any given time. Studies may focus on effective means of treatment, better ways of treating the disease, improving the quality of life for patients, or appropriate care in remission or after cures.
"Don't Shop ... Please Adopt"
If you can’t find the pet you’re looking for on Petfinder, don’t give up. Some shelters maintain waiting lists for specific breeds, so don’t be afraid to ask! There are also breed-specific rescues for just about every breed, and most of them post their pets on Petfinder. (Petfinder can even e-mail you when a pet that fits your criteria is posted — just click “Save this Search” at the top of your search results page.)
Jeff Gold, Founder, Rescue Me! Animal Rescue Network
Jeff Gold lives in Watkinsville, Georgia on the same property as Rescue Me's Animal Rehabilitation Center, with 18 rescue animals. Shown with him in the photo to the left are Maggie, Izzie and Cortez. In 2003, after learning there was nobody doing boxer rescue work in Georgia, Gold founded Boxertown, an organization which helped find homes for over 500 boxers during its first two years. Based upon this success, Gold came up with the vision for Rescue Me! ― a network which helps all breeds of dogs, cats and other animals find good homes, anywhere in the world. RescueShelter.com is also a free service of Rescue Me! and provides the world's largest and most up-to-date directory of animal rescue organizations for all breeds of dogs, cats and other animals, including a comprehensive directory of wildlife rehabilitators in over 150 countries.